The successful rise of the edupreneurs in this century and the next will be affected by the interrelationship and collaboration of the educator as a change agent and the online instructional designer as an enabler and co-designer with the educator as they create irresistibly engaging learning experiences for learners. Keep in mind that a new vision of e-learning sees the purpose of education as to mentor and guide students to become creators of new knowledge and skill sets that will impact their respective societies. Constant innovation becomes a new norm for the new edupreneurs. A properly designed global E-Learning education complex becomes the incubator for the development of skill sets and mind sets necessary to nurture the rise of edupreneurs. The dependency on sustained collaboration among those who would be the architects of this complex is necessary and achievable, given the continued development of useful technology and transformative pedagogy.